To explore the clinical effect and mechanism of Chinese medicine Fuzheng antiseptic lotion in the treatment of infant vulvovaginitis. Methods：Patients were randomly divided into Chinese medicine Fuzheng antiseptic lotion treatment group (n=40) cases and 5% povidone iodine solution control group (n=40). Main symptoms and signs were observed and compared before and after treatment. And the mechanism of traditional Chinese medicine was analyzed. Results：Total clinical effective rate of treatment group and control group were 97.5% and 90%; the curative rate were 75% and 50%，which showed significant differences (P<0.05)，and the recurrence rate were 10% and 40%，which showed significant differences between the two groups (P<0.05).Conclusion：Traditional Chinese medicine Fuzheng antiseptic lotion in the treatment of infant vulvovaginitis has reliable curative effect，it works to clear heat and remove dampness，detoxification and relieve itching，and it can improve the local resistance centralizer，thereby reduce the recurrence rate. Besides，there were no obvious clinical adverse reactions.