To explore the effect of Adipose Tissue-Derived Mesenchymal Stromal cells (ADMSCs) which is Injectable Bone Regeneration Composite (IBRC) combined with intra-gastric administration of Assemble Flavone of Drynaria Rhizome(AFDR) on rabbits with lumbar transverse interbody fusion. Methods：Sixty adult rabbits were made into rabbit lumbar transverse interbody fusion models，randomly divided into five groups including A group (IBRC+AFDR)，B group (IBRC+ Autologous iliac Crest Bone(ACB) + Deionized Water (DW))，C group (IBRC+ADMSCs+DW)，D group (ACB+DW)，E group (ACB +AFDR). After eight weeks of treatment，specimens were collected for gross observation，touch detection，X-ray，histological observation. Results：The fusion rates of group C and group E were significantly higher than that of group B (P<0.05)，and there was no significantly statistical difference (P>0.05)compared with the group D. Conclusion：IRBC composite ADMSCs can achieve a similar fusion rate as ACB group. Combing with traditional Chinese AFDR can improve the rate of the intertransverse lumbar fusion in rabbits.