To develop IRP rabbit model. Methods： Thirty New Zealand rabbits were randomly divided into normal group and model group. Three methods were conducted to make the rabbit models. The three methods contain rhubarb and senna gavage，perianal injection of anhydrous alcohol and stand. The prolapse of rectal mucosa under the anus mirror and the microscopic structure of rectum between the normal group and the model group were compared. Results： Compared with the normal group，internal rectal prolapse were significantly different in the model group. Pathological findings were in accordance with IRP standards. Conclusion： Composite method of IRP rabbit model is reliable.