To observe the expressions of AQP1 and AQP8 in lung and colon tissue of mice with Sjogren's syndrome. Methods：Fifty BALB/c mice were randomized into five groups，with10 mice in each group. The mice models with Sjogren's syndrome were established by immune inducing method. It was able to produce the specific clinical symptoms and pathological changes of Sjogren's syndrome. The effect of Zengye decoction on the expression of AQP1/AQP8 in lung and colon tissue was observed by immunohistochemistry and Western blot. Results：Zengye decoction can strengthen the AQP1 protein expression in lung and colon tissue (P<0.01)，however AQP8 was barely changed. Conclusion：It could be one of the causes of Sjogren's syndrome that AQP1 expression was reduced in multiple organ in the mice with Sjogren’s syndrome. Zengye decoction can increase the body fluid，and the effect may be associated with the increased AQP1 expression.