To explore the effect and mechanism of Jianglu powder (JLP) in absorbing pus and removing slough on infected wound surface of rats. Methods：Rat models of infected wound surface on the back were successfully established. The model rats were randomly divided into the JLP group，the Jiuyi Powder (JYP) group and the model group. The wound surfaces of rats in JLP group were treated with JLP，while those in JYP group were given JYP every day. The wound surfaces of rats in model group were only treated with normal saline (NS) every day. The treatment lasted for fourteen days. The rats’ general situation and the dropping off time of pus and slough were observed. On the 3rd，7th，and 14th day，the amount of wound surface secretion was calculated. The level of macrophages lysosome in wound tissues was detected by immunohistochemistry; the content of IL-1β in wound tissues was detected by ELISA. On the 7th and14th day，serum liver and renal function indexes were detected by enzymic method. Results：In terms of the dropping off time of pus and slough，JLP group and JYP group had significantly shorter results compared with the model group (P<0.01). As for score of wound surface secretion，on the 3rd day，JLP group and JYP group showed significantly higher outcomes than model group(P<0.01).In terms of the level of macrophages lysosome in wound tissues，on the 3rd and 7th day，JLP group and JYP group had significantly higher scores than the model group(P<0.01).The content of IL-1β in wound tissues on the 3rd and 7th day in JLP group and JYP group were significantly more than those in model group(P<0.01). Serum total BUN，CREA and ALT：on the 7th and 14th day in JYP group was significantly higher than JLP group and model group(P<0.05).Conclusion：JLP could absorb pus and remove slough of infected wound surface by increasing the level of macrophages lysosome and IL-1β in wound tissues. The safety of JLP is better than Shengdan preparation (JYP).