To investigate the effect and mechanism of Yishenhuazhuo granules on Adenine feeding method induced chronic renal failure Rats. Methods： The rats were fed with 0.75% adenine to make the models of chronic renal failure，then they were randomly divided into six groups，including blank control group，model control group，Niaoduqing granules control group and Yishenhuazhuo granules with large，medium and small dosage groups. After administered continuously for 30 days，kidney index were calculated，Bun and Crea content in serum were determined by using ELISA method，and renal pathological changes were observed by using HE staining. Results： Compared with model control group of drug-treated rats，kidney index differences were not statistically significant，serum Bun and Crea were significantly reduced in each administration group，and tubular dilatation in Yishenhuazhuo granules large dosage group was slight (P<0.05).Conclusion： Yishenhuazhuo granules could reduce Bun and Crea content in serum in Adenine feeding method induced chronic renal failure rats，and improve renal pathological changes.