To investigate the effect of Qili Qiangxin capsule on senile patients with cardio-renal syndrome (CRS).Methods： A total of 76 elder patients with diagnosis of CRS in our department in last 2 years were divided into control group and treatment group randomly，each group had 38 cases.The control group received regular therapy according to guideline of heart failure (AHA，2011).The patients of treatment group took the medicine of Qili Qiangxin capsule on the basis of routine therapy，and the recommended dosage was 4 capsules every 8 hours for 12 weeks.Observation index include NYHA-FC，LVEF，LVDd，NBP，Scr，and GFR.Results： 1) Comparison of clinical effect：The total effective rate was 71.1% in control group and 92.1% in treatment group，and the difference was significant (P<0.05); 2) LVEF increased significantly in each group after 12 weeks treatment，while LVDd and NBP reduced.The improvement was more significant in treatment group.3) The level of Scr reduced and GFR increased significantly in treatment group than those in control group.Conclusion： Qili Qiangxin capsule could improve the cardiac and renal function and quality of life in elder patients with CRS without adverse reaction.