To investigate the curative effect of QingGan JieDu ZhiKe Prescription from Dezhou Hospital of Traditional Chinese Medicine on chronic cough after virus infection. Methods： Take the method of random, contrast, double blind for research. Divided patients that accorded with our research standards into treatment group and control group. Patients in the treatment group were treated by QingGan JieDu ZhiKe Prescription, meanwhile the control group was treated by budesonide and formoterol fumarate powder for inhalation. Differences on curing time, the improvement of symptom, living quality and the recurrence rate were compared two weeks after treatment. Results： Through comparison, treatment group took less time to be cured compared to the control group (P<0.05). After two weeks of treatment, living quality in the treatment group was better improved than that in the control group (P<0.05). Two weeks after the treatment was finished, recurrence rate in the treatment group was lower than that in the control group (P<0.05). Conclusion： QingGan JieDu ZhiKe Prescription has significant advantage on course of treatment, improvement of living quality and recurrence rate control on chronic cough after virus infection. It is worth using in clinical practice.