To observe the effect and explore the mechanism of Suanzhiqing capsule on renal function and TNF-α level in Nephropathy Rats with Uric Acid. Methods： Male SD rats were divided into five groups including normal group, model group, sodium chloride group, suanzhiqing capsule treatment group, and allopurinol treatment group. Nephropathy rat with uric acid were established by giving adenine and ethambuto. Then model rats were administered intragastrically with sodium chloride, suanzhiqing capsule, or allopurinol for three weeks. The blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA) in blood and tumor necrosis factor alpha (TNF-α) in renal tissue were determined. Results： (1) Compared with the normal group, the levels of BUN. Cr, and UA in blood in model group significantly increased (P<0.05). (2) Compared with the sodium chloride group, the levels of BUN, and UA in blood in suanzhiqing capsule treatment group and allopurinol treatment group significantly decreased (P<0.05). Although the levels of Cr in allopurinol treated group decreased, only in suanzhiqing capsule treated group were significantly. (3)Comparing the levels of BUN. Cr, and UA in suanzhiqing capsule treatment group with those in allopurinol treatment group, there was no significant difference between the two groups (P>0.05). (4) The optical density value of TNF-αin renal tissue of the sodium chloride group was significantly higher than that in normal group(P<0.05).The optical density value of TNF-αin renal tissue of suanzhiqing capsule treatment group and allopurinol treatment group were significantly lower than that in sodium chloride group (P<0.05). (5) Compared with the model group, uratic crystallization and inflammatory cell infiltration were significantly reduced, and tubular expansion had been relieved in both suanzhiqing capsule treatment group and allopurinol treatment group. Conclusion： Suanzhiqing capsule could reduce the levels of BUN. Cr, and UA in blood of nephropathy rats with uric acid, decrease uratic crystallization and inflammatory cell infiltration, and lower TNF-α level in renal tissue, thus it could have a beneficial effect on uric acid nephropathy rats.