To establish the optimal extraction technology for Ruanjian Qingmai decoction. Methods：With the extraction rate and the content of Qirenchun and Cinnamic acid as indexes, choose the best extraction technology by orthogonal design. Results： The best extraction process was as follow： the ratio of sample to water was 1：8, soaking for 0.5 hours, extracting for 2 hours, 3 times of extraction. Conclusion： The optimal extraction technology is rational, stable and feasible.