Mori Cortex， belonging to the Lung Meridian， is known for its anti-athma and diuresis effects.This work provided a systemic review of the latest findings on chemical constituents， pharmacological activities as well as pharmacokinetic profiles of this medicinal herb and its main constituents， with aims to better understanding the underlying mechanisms of the health benefits of the herb， the essence of the Meridian theory in traditional Chinese medicine， as well as to promote safe and effective clinical use and new product development.