In accordance with the theory of medicinal nature, we explored new ways of reducing toxicity of Fuzing by combining it with other medicinal herbs.Methods：By conducting toxicological experiments (acute toxicity in combination with cardiac toxicity), we tested four combination theories, i.e. using cold medicinal to inhibit hot medicinal, using sweet medicinal to relieve toxicity, using soft medicinal to curb tough medicinal, modifying toxicity.Results：Compared with combining with medicinal of sweet, or soft, or modifying nature, the combination with cold medicinal proved to be most significant at reducing Fuzi’ toxicity.Conclusion：The theory of medicinal nature provides a new thinking and method to reduce Chinese medicine’s toxicity.