To explore clinical effect of No.Ⅱ Qingre Huayu (clearing heat and resolving stasis) in treatment of ischemic stroke and its effect on neurological deficit scores and TCM syndrome scores.Methods：One hundred and twenty patients with ischemic stroke in our hospital from June 2012 to September 2013 were randomly divided into control group and observation group， with 60 cases in each. Patients in the control group were given nimodipine on the basis of the conventional treatment while the observation group was given No.ⅡQingre Huayu formula.The clinical effect， neurological deficits and TCM syndrome scores before and after treatment were compared between the two groups.Results：The total effective rate of the observation group was 93.33%， which was significantly higher than that of the control group (76.67%) (P<0.05); after treatment， the neurological deficit and TCM syndrome scores of the observation group were 10.63±1.01 and 14.92±2.06， which were significantly lower compared with the scores before treatment and those of the control group (P<0.05).Conclusion：The therapeutic effect of No.Ⅱ Qingre Huayu formula in treatment of ischemic stroke is significant， and it can significantly promote the recovery of neurological function.It is safe and effective， which is worth of being promoted and applied in clinical practice.