To study the immediate hypoglycemic effect of Andrographis-fermented honey oral solution formula “JAMSI” (produced by PT Mahkotadewa Indonesia; registered at Indonesian Food and Drugs Authority：TR053649111) among 34 hyperglycemic volunteers.Methods：This study was designed as a pre and post treatment’s effect evaluation among hyperglycemic volunteers. Volunteers were recruited from visitors to the “JAMSI” boothe during the study, who were hyperglycemic and ready to be tested with the “Jamsi” remedy under study. Their blood sugar were tested using glucometer Accu-Chek Active (made in Germany) before and one hour after consuming the “JAMSI” oral solution. The paired blood sugar data were analyzed using student-t test with paired samples, one sided, with significance cut off point α=0.05.Results：During two study days on 16th and 23rd February 2013 in Jakarta, there were 34 volunteers eligible to the study. They consisted of 20 female and 14 male, among which 20 volunteers were still consuming western hypoglycemic medicine. Their age ranged from 22 to 74 years (52.26 ±10.10 years), with diabetes mellitus history ranging from 1 to 33 years (9.36±8.27 years).Their average capillary blood sugar level before consumption of the tested “jamu” remedy was (243.03±97.97) mg/dl and one hour after consumption of the remedy was (197.94±100.01) mg/dl. The difference was highly significant (P<0.01). Analysis upon those with initial blood sugar above 200 mg/dl versus those with lower than 200 mg/dl indicated that the reduction of blood sugar level was more prominent among those with higher initial blood sugar level (table-3). The hypoglycemic effect was not significantly differently (P>0.05) between those still consuming oral antidiabetic drugs and those not consuming oral antidiabetic drugs.Conclusion：The “JAMSI” remedy under study showed very significant immediate hypoglycemic effect and apparently free from serious utoward effects among the tested volunteers. More studies are required to assess the medium and long term effects of the “JAMSI” remedy.