To observe effect of Shenshuai Guanchangye and continious blood purification on micro inflammation index of sepsis induced early acute kidney damage. Methods： Thirty patients meeting the inclusion criteria were randomly divided into treatment group (n=15) and control group (n=15). Patients in the treatment group were given Shenshuai Guanchangye as well as conventional medicine, and the control group applied conventional medicine. Therapeutic effects of the two groups after one week of treatment were compared, and the level of IL-6 and IL-8 in plasma before and after treatment were determined. Results： The therapeutic effect of the treatment group (86.6%) was significantly higher than that of the control group (53.3%); before the treatment, there was no significant difference in terms of the level of IL-6 and IL-8 in plasma; after the treatment, the level of IL-6 and IL-8 were significantly decreased in the treatment group (P<0.05). Conclusion： Shenshuai Guanchangye and continious blood purification shows satisfactory effect on micro inflammation index of sepsis induced early acute kidney damage.