To investigate the changes of cardiac function in patients with sepsis and their influence on prognosis. Methods：All enrolled patients were inserted PiCCO catheters and mortered hemodynamics by PiCCO monitor. Mean artery pressure (MAP), cardiac index (CI), extravascular lung water index (ELWI), dPmax and systemic vascular resistance index (SVRI) were recorded. Echocardiography was done when a patient was enrolled and on the 7th day after admitted. Left ventricular eject fraction (LVEF), E and A peak of mitral blood velocity, mitral annulus moving speed (E’), E/A and E/E’ were calculated. All patients were divided into t the surviving group and the death group according to the prognosis.Results：The CI of all enrolled patients increased and SVRI decreased significantly. MAP, CI, ELWI and SVRI in the surviving group approached to normal gradually, significant differences of time effect were found (P<0.05). The trend in the death group was on the contrary, significant differences were found between the two groups (P<0.05). E/E’ in the surviving group was higher than normal (E/E’<8) in the whole protocol. Whereas in the death group, LVEF and E/E’ were worsen gradually, significant differences between the two groups were found too (P<0.05) Conclusion： The occurrence of diastolic cardiac dysfunction in sepsis patients is more common than that of systolic cardiac dysfunction. It can be found earlier than systolic cardiac dysfunction. The restoration of diastolic cardiac dysfunction is slower than that of systolic cardiac dysfunction.