To observe the protective effect on kidney function of the combined application of Atomolan and Bailing capsule in treating diabetic nephropathy with hypertension.Methods：Three hundred and sixty six patients with diabetic nephropathy were randomly divided into Atomolan group， Bailing capsule group， and the combined treatment group.Except from the basic general treatment， patients were respectively given Atomolan， Bailing capsule and combined treatment for two months.The levels of blood pressure， diastolic blood pressure， blood urea nitrogen， creatinine， urine albumin， β2-microglobulin before and after treatment were measured.Results：Compared with the only application of Atomolan or Bailing capsule， the combined application of both drugs further decreased the level of urea nitrogen， creatinine， urine albumin， and β2-microglobulin (P<0.05).Conclusion：The combined application of Atomolan and Bailing capsule shows reliable therapeutic effect and definite protective effect on kidney in treating diabetic nephropathy hypertension.