To observe the efficacy and adverse reactions of Kangai injection plus chemotherapy in the treatment of advanced non-small cell lung cancer( NSCLC) .Methods：Seventy-two cases with advanced NSCLC were randomly divided into two groups，36 patients of test group were treated with Kangai injection combined with chemotherapy，36 patients of control group were only treated with chemotherapy.The chemotherapy effect，side effects and improvement of thequality of life of two groups were evaluated during and after chemotherapy.Results：Kangai injection combined with chemotherapy group and the clinical benefit rate was slightly higher than the single chemotherapy group, the difference was statistically significant (P<0.05).Toxicity of Kangai combined chemotherapy group chemotherapy is lower than the single chemotherapy group, the difference was statistically significant (P<0.05).Kangai combined chemotherapy group quality of life is better than simple chemotherapy group, there was significant difference between 2 groups (P<0.05).Conclusion：Kangai injection can improve the curative effect in patients with advanced non small cell lung cancer, reduce the side effects of chemotherapy, improve the quality of life.