To prove if the internal medical treatment plus the anti-inflammatory analgesic cream have better effect to alleviate active rheumatoid arthritis joint pain than the single application of internal medical treatment. Methods： The clinical design followed with the principle of randomization, control, repetition and adopted double-blind method. The 72 patients with active RA pain were randomly (1：1) assigned to two groups, the anti-inflammatory analgesic cream group and the placebo group. The primary efficacy endpoint was observed. Results： The effect of the anti-inflammatory group was better than that of the placebo group (P<0.05). Conclusion： The anti-inflammatory analgesic cream can effectively alleviate the joint pain of active period of RA. It has better safety.