To explore the clinical efficacy of Chinese medicine treating infertility. The notable traditional Chinese medicine doctor Li Xiangyun is famous for her experience in treating infertility and difficult miscellaneous diseases, called as “children-delivering grandfather”. In recent years, he applies traditional Chinese medicine in treating IVF-ET patients who failed to conceive, or promotes nature conception, or improves the success rate of planting. This paper summarized two classical cases of Professor Li treating infertility with traditional Chinese medicine, which are believed to be worth being applied clinically.