To explore the efficacy of TCM treatment on diabetic patients with periodontitis.Methods：70 diabetic patients with periodontitis were divided into control group (n=31)and observation group（n=39). Patients in the control group were treated with step periodontitis therapy. The observation group gave patient Chinese medicine treatment according to the situation of diabetes apart from the same therapy of the control group. The efficacy of treating periodontitis，blood sugar levels， and related biochemical indicators in the two groups were observed.Results：The fasting plasma glucose (fpg) level in the observation and the control group were (7.48 ± 1.06 mmol/L vs 8.54 ± 1.32 mmol/L)， hemoglobin (HbAlc) were (7.46 ± 2.14% vs9.31 ± 2.73%)， treatment efficiency were (94.9% vs67.7%)，the full-mouth plaque index (pli) level after 2m were (1.68 ± 0.32 vs2.05 ± 0.51)，the probing depth (ppd) levels were (2.15 ± 1.30 mm vs3.15 ± 1.12 mm)， the periodontal attachment level measurement (pal) levels were (7.10 ± 1.82 mm vs7.59 ± 1.82 mm)， the tooth mobility (md) levels were (0.69 ± 0.72 mm vs1.65 ± 0.42 mm)， the calcium (ca) levels were (2.10 ± 0.12 mmol/L vs2.40 ± 0.22 mmol/L)， the inorganic phosphorus (P) levels were ( 1.29 ± 0.14 mmol/L vs1.33 ± 0.20 mmol/L)，P<0.05.Conclusion：TCM treatment on diabetic patients with periodontitis has satisfactory efficiency， fewer side effects， treating both the symptoms and roots. However， the selection of prescription requires differentiation of diabetes type.