To explore the association between traditional Chinese medicine(TCM) pathological factors and the biochemical indicators of “addiction” relapse of drug abusers. Methods： Three hundred and fifty four cases of drug addicts from compulsory detoxification institute of Fuzhou city and the jurisdiction of the Department of Justice of Fujian Province volunteered for the study. Information on four diagnostic methods was collected， and TCM pathological factors were extracted by using syndrome elements differentiation. Besides， liver and kidney function， blood lipids， blood glucose index were tested. Results： 1）Levels of liver function and blood lipid of the drug addicts were significantly higher than those of the healthy group; level of kidney function of the judicial group was lower than that of the healthy group; level of blood glucose of the public security group were significantly lower than that of the healthy group， while the judicial group were higher than that of the healthy group. 2）As for disease location， gallbladder was significantly related to CREA in both of the public security group and the judicial group; as for the nature of disease， Yin deficiency was significantly associated with BUN. Conclusion： Metabolism is relevant to TCM pathological factors in drug addicts during the rehabilitation period. Biochemical indicators can be taken as relevant evidence for syndrome elements differentiation.