In Traditional Chinese Medicine， the overall pathogenesis of perimenopausal syndrome is the imbalance of yin and yang.This syndrome mainly locates in kidney， and organs such as heart， liver and spleen.The clinical manifestations are diverse and complex.As for treatment， harmonizing yin and yang is the basic rule.Treatment based on syndrome differentiation and individualized therapy are also absolutely necessary.Only by combining cold and heat， tonification and purgation can get the best therapeutic effect.