To observe the effects of Herbs-Partitioned moxibustion on the positive mucus layer thickness and Na+/K+-ATP enzymatic activity in rabbits with acute gastric mucosal lesion for exploring the mechanisms of moxibustion action on model of acute gastric mucosal lesion.Methods：Anhydrous ethanol damage is adopted to establish model of gastric mucosal lesion.30 of 40 rabbits were randomly selected as model group，the rest as control.After the successful models were confirmed，30 model rabbits were randomly allocated to model group，herbs-partition moxibustion group and western medicine group.Herbs partition moxibustion group were treated by moxibustion on Housanli points，6 columns once a day.Western medicine group were administrated by gavage at dosage of 25 mg/kg a day.The other groups just fixed the same as herbs-partition moxibustion group without any treatment.The treatments continued for 7 days.the gastric mucosa and tissues of Housanli points were collected on 8th day，corresponding procedures were done at request of experiment.Results：The positive mucus layer thickness of herbs-partition moxibustion group was more significantly increased than those of model group(P<0.05).The Na+/K+-ATP enzymatic activity of herbs-partition moxibustion group was significantly increased than those of model group.Conclusion：Improving the local energy metabolism of local acupoint in rabbits with acute gastric mucosal lesion may be one of the mechanisms of restoring and protecting the mucosal lession.