To investigate the effects of Tangzhiping on glucose and lipid metabolism in rats with insulin resistance. Methods：Sixty male SD rats which were 8 weeks old and weighted among 180 to 200 g were randomly divided into blank control group (n=15) and module group (n=45) after being fed for a week for adaptation. Rats in the blank control group were fed with common food， while module group fed the rats with high fat food for 8 weeks. Eight weeks later， the model rats were successfully made， and they were randomly divided into： the model group (n=15)， Tangzhiping group (n=15)， rosiglitazone group (n=15). Tangzhiping group gave the rats Tangzhiping formula particles according to the statement 20 g/kg/d to fill in the stomach; rosiglitazone group applied up to 0.8 mg/kg/d rosiglitazone gavage; model group and blank control group used the same amount of saline solution for 8weeks. Twelve hours after the last administration， levels of insulin sensitivity was evaluated by the “euglycemic hyperinsulin clamp technique”， and levels of body weight， fast plasma glucose， serum insulin， blood lipids were also observed. Results： Tangzhiping could raise insulin sensitivity， improve IR， suppress weight gain which was better than rosiglitazone; it could lower blood sugar， reduce serum insulin， TG and LDL-c， which was close to the efficacy of rosiglitazone. Conclusion： IR model is successfully established. Tangzhiping and rosiglitazone can lose weight， reduce blood sugar and insulin levels， adjust blood lipid levels and increase insulin sensitivity.