Traditional Chinese medicine (TCM) is an important approach for treating cancer in China. Its mechanisms relate to regulate the bodys internal environment and remodel the tumor microenvironment (TME)， which coincided with modern cancer treatment views targeting on the TME. Here we introduce how TME reforming and its functions in tumorigenesis， and furthermore illustrate the effects and mechanisms of TCM regulating TME via reshaping immunosuppressive cells and enhancing anti-tumor immune responses. We also reveal the TCMs bidirectional and multi-targeting functions on regulating TME. Hopefully， it provides new theoretical basis for TCM clinical practice in the cancer treatment and prevention.