To observe the effects of external application of traditional Chinese medicine combined with oral administration of oxycodone for the treatment of medium and severe cancer-induced pain. Methods： Fifty patients with cancer pain were randomly divided into treatment group (n=25) and control group (n=25) by the method of block randomization. Both groups gave patients oxycodone according to the dosage titration， and the treatment group applied traditional Chinese medicine (TCM) solution to the raw skin at the same time， 3 to 5 times a day for 3 weeks. The effect in the two groups， the dosage of oxycodone and constipation condition were observed. Results： The pain control of the treatment group was obviously better than that of the control group (P<0.05)； the dosage of oxycontin in treatment group was decreased significantly (P<0.05) compared with the control group； the incidence rate of constipation of the control group was higher than that of the treatment group (P<0.05). Conclusion： Integrated traditional Chinese and western medicine in controlling cancer -induced pain can increase curative effect and reduce the occurrence of constipation