多囊卵巢综合征中医证型与糖代谢及IGF-I、IGFBP-1相关性的研究
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广东省中医药局课题(项目编号:20130601;项目名称:健康指导配合中药对肥胖型PCOS患者胰岛素生长因子-I、胰岛素生长因子结合球蛋白-I的影响)


Study on the Relationship between TCM Differentiation Types of Polycystic Ovary Syndrome and Glycometabolism, IGF-I and IGFBP-1
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    目的:拟探讨多囊卵巢综合征(PCOS)患者中医证型分布规律及与糖代谢、炎性因子IGF-I、IGFBP-1的关系。方法:对120例PCOS患者进行中医证候调查,同时检测患者BMI、胰岛素抵抗稳态模式评估及胰岛素生长因子-I(IGF-I)、胰岛素生长因子结合球蛋白-1(IGFBP-1)水平。并探讨中医证型与糖代谢异常、IGF-I、IGFBP-1的关系。结果:临床辨证分为肾虚、脾虚痰湿、肝郁气滞,构成比分别为35%,33%,32%。各证型间比较P>0.05,差异无统计学意义。脾虚痰湿组BMI、FINS、Homa-IR,P均<0.05,差异具有统计学意义,脾虚痰湿组IGFBP-I较肾虚、肝郁气滞组下降,P均<0.05,差异具有统计学意义,脾虚痰湿组IGF-I与肾虚、肝郁气滞组高比较升高,差异无统计学意义(P>0.05)。结论:PCOS中医证型以肾虚、脾虚痰湿、肝郁气滞为主,脾虚痰湿证与胰岛素抵抗、IGFBP-I下降有关。

    Abstract:

    To investigate the regularities of distribution of TCM differentiation types of polycystic ovary syndrome, and its relationship with glycometabolism and inflammatory factors IGF-I and IGFBP-1. Methods: The TCM differentiation types of 120 cases of PCOS patients was investigated, and at the same time their BMI, homeostasis model assessment insulin resistance and insulin growth factor-I (IGF-I), insulin like growth factor binding immunoglobulin-1 (IGFBP-1) of patients were measured. The relationship between the TCM differentiation of polycystic ovary syndrome and glycometabolism, IGF-I and IGFBP-1 were explored. Results: TCM differentiation types included kidney deficiency, phlegm-dampness due to deficiency of the spleen, stagnation of liver qi, and the constituent ratio was 35%, 33%, and 32%. The difference in all the three groups was not significant, P>0.05. The levels of BMI, FINS, Homa-IR of phlegm-dampness due to deficiency of the spleen were higher than those of the other two groups, and the differences remained significant, P<0.05. The level of IGFBP-I of phlegm-dampness due to deficiency of the spleen was lower than that of the other two, and the differences remained significant, P<0.05. The level of IGF-I phlegm-dampness due to deficiency of the spleen was higher than that of the other two, and the difference was not significant, P>0.05. Conclusion: The TCM differentiation types of polycystic ovary syndrome mainly included kidney deficiency, phlegm-dampness due to deficiency of the spleen, stagnation of liver qi. The syndrome of phlegm-dampness due to spleen deficiency was relevant to insulin resistance and decline of IGFBP-1.

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郑洁莉 徐 莉.多囊卵巢综合征中医证型与糖代谢及IGF-I、IGFBP-1相关性的研究[J].世界中医药,2014,9(07).

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  • 收稿日期:2014-01-17
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  • 在线发布日期: 2014-07-17
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