To explore the clinical features of chronic plague-type psoriasis patients with TCM syndrome of phlegm-obstructing and disharmony between yingfen and weifen. Methods： We collected clinical data of 173 patients with chronic plaque-type psoriasis in 1 year followed-up period to find the difference between TCM syndromes. Results：Patients with the TCM syndrome of phlegm-obstructing and disharmony between yingfen and weifen were often seen symptoms such as anidrosis， feeling oppressed， heavy head as if swathed， heavy limbs， regular pain， lethargy， plump tongue， dark purple colored tongue， sublingual varices， greasy coating and stringy pulse， and showed less satisfactory treatment result (P<0.05). Conclusion： Chronic plague-type psoriasis patients with TCM syndrome of phlegm-obstructing and disharmony between yingfen and weifen were different from psoriasis patients of other syndromes in terms of symptoms and therapeutic methods， therefore they should be distinguished carefully， and treated properly.