To study the influence of Xiaofeng Xuanqiao decoction on behavior and cytokines in allergic rhinitis models， and explore the therapeutic mechanism.Methods： Forty guinea pigs were randomized into 4 groups， normal control group， allergic rhinitis (AR) group， Xiaofeng Xuanqiao decoction group， and loratadine group. Allergic rhinitis models of guinea pigs were made by 10% TDI. Xiaofeng Xuanqiao decoction and loratadine were applied to inAR guinea pigs. The serum levels of IL-5 and IL-12 were determined by ELISA methods. Results： Xiaofeng Xuanqiao decoction could obviously relieve the hypersensitivity and infiltrate the inflammatory cells on the nasal mucosa. The serum level of IL-5 in Xiaofeng Xuanqiao decoction group significantly decreased compared with that of AR group(P<0.01)， and the serum level of IL-12 in Xiaofeng Xuanqiao decoction group significantly increased (P<0.01). There is a positive correlation between them. The therapeutic effect of Xiaofeng Xuanqiao decoction group was better than that of loratadine group. Conclusion： The therapeutic mechanism of Xiaofeng Xuanqiao decoction on allergic rhinitis is decreasing the level of IL-5 and increasing the level of IL-12， which suggests that IL-5 and IL-12 are important factors in the pathogenesis of AR.