To set up the infrared spectrum of herba gendrussae， so as to provide reference for its quality control. Methods： The 12 batches of Herba Gendrussae were measured by infrared spectroscopy and the common infrared spectrum fingerprints was set up， then their similarities were calculated by compared the common model. Results： The common infrared spectrum fingerprint of Herba Gendrussae was set up， and 12 batches of sample similarity were in the range of 0.9739 to 0.9965. Conclusion：This method is with good repeatability and stability， and it is simple， fast， and sensitive， which can be used as a qualitative method for herba gendrussae.