Proteinuria is one of the main clinical symptoms of kidney disease， and according to traditional Chinese medicine， protein attributes to the category of “subtle matter”. Pathogenesis of proteinuria is formed mainly from two aspects， which are root vacuity and tip repletion， as well as healthy energy deficiency and evil excess. The root vacuity includes functional disorders of spleen， kidney， lung， and liver. The tip repletion includes factors such as external infection， dampness heat， blood stasis， emotion. Clinical treatment usually utilize methods of tonifying spleen and stomach， supplementing kidney and securing and astriction， boosting qi and nourishing lung， harmonizing blood and adjusting liver， clearing heat and eliminating dampness， activating blood and transforming stasis to cure primary glomerular proteinuria which shows satisfactory therapeutic effect.