To investigate effects of relevant factors including clinical implications，lung disease and physiological variables and TCM syndrome integral on the prognosis of patients with idiopathic pulmonary fibrosis (IPF).Methods：Forty-eight patients with IPF according to clinical diagnosis underwent dyspnea score，pulmonary function tests and arterial blood gas test.The Kaplan-Meier test was used to estimate the survival rate in the two groups，and Coxproportional hazard regression was taken to evaluate Hazard Ratio in the IPF patients.Results：During the37 months of follow-up，the median survival time was 37.35 months after diagnosis.The univariate Cox proportional hazards regression analysis showed that TCM syndrome integral，BMI，6 minutes walk test and FVC %，TLC %，DLCO %，PO2，ESR，clubbing fingers were the factors affected the prognosis of patients with IPF (P<0.05).The multivariate Cox proportional hazards regression analysis showed that BMI，6 minutes walk test，ESR were the main influence factors for the prognosis of patients with IPF.Conclusion：BMI，TCM syndrome integral，6 minutes walk test and TLC %，DLCO %，PO2，ESR，clubbing fingers were the influence factors of the prognosis of patients with IPF，among which the BMI，6 minutes walk test，ESR were the main influence factors.