To observe the curative effect of the Feiwei medicinal instant granules on pulmonary interstitial fibrosis and effect on tumor markers of CA19-9.Methods：One hundred and twenty patients with pulmonary interstitial fibrosis were randomly divided into treatment group (n=61) and control group (n=59)，and all of them were given fundamental treatment.Patients in the treatment group also received oral administration of Feiwei medicinal instant granules for consumptive lung disease twice a day，100ml a time.Patients in the control group were given oral administration of prednisone once a day，30mg each time.After 2 months of treatment，a series of changes of the two groups before and after the treatment，including：TCM score，dyspnea scores，six-minutes walking test，TLC，FVC，FEV1，FEV1/FVC，DLCO and tumor markers of CA19-9 were observed.Results：The total effective rates of TCM syndrome in treatment group and control group were respectively 61.7% and 34.8%，and there was significant difference between the two groups.In the treatment group，TCM score，dyspnea scores，six-minutes walking test，TLC，FEV1，and tumor markers of CA19-9 were improved obviously（P<0.05 or P<0.01）.In the control group，the part of TCM score，dyspnea scores were relatively improved，too（P<0.05）.However，the treatment group was superior to control group in the improvement of TCM syndromes，dyspnea scores，six-minutes walking test，FVC and tumor markers of CA19-9.Conclusion：Feiwei medicinal instant granules can effectively relieve the symptoms of dyspnea in patients with pulmonary interstitial fibrosis，increase exercise tolerance，enhance the TLC，FEV1 in lung function，and bring patients more satisfaction.The medicinal instant granules may inhibit apoptosis of epithelial cells of IPF and abnormal proliferation.