To observe the influence of Danhong injection on the coagulation and local microcirculation of patients with lower extremity fractures.Methods：Patients with lower extremity fractures treated in our hospital from September 2012 to February 2013 were randomly divided into control group (n=72) and observation group (n=72).All the patients were treated with internal fixation treatment，and patients in observation group were also treated with danhong injection，40ml/time/day，for 2 weeks.Then the indexes of bone metabolism，coagulation and local microcirculation of two groups were compared.Results：After 7，28 days of treatment，the serum levels of BALP，BGP and PICP of observation group were all higher than those of the control group; the ET and CRP were lower than those of control group; and the TT，PT，APTT，Fb of observation group were significantly shorter than those of the control group; the indexes of nailfold microcirculation such as form integral，flow state integral，points around the state and total integral of observation group were all significantly lower than those of the control group; the capillary flow rate was much faster in observation group; white micro-bolt of the observation group was lower than that of control group，all P<0.05.Conclusion：Danhong injection can effectively improve the coagulation and local microcirculation of patients with lower extremity fractures，and benefit the patients bone healing.