To observe the clinical efficacy of Yiqi Congming decoction in refractory low intracranial pressure headache after lumbar puncture.Methods：Retrospective study was conducted，and all the 11 patients showed low intracranial pressure headache after lumbar puncture.All the patients were given Yiqi Congming decoction once a day for five days.The visual analogue scale (VAS score) and headache intensity of patients were recorded before and after treatment to determine the efficacy.The efficacy score was rated for statistical analysis.Results：After treatment，the VAS score of the patients was 2.85±1.76，which was significantly lower than that before treatment(7.54±2.23)，and the difference was statistically significant (P<0.05); the headache intensity was 0.82±1.04，which was significantly lower than that before treatment(2.36±0.54)，and the difference was statistically significant (P<0.05).Headache relieved significantly after treatment.Conclusion：The clinical efficacy of the treatment of Yiqi Congming decoction in refractory low intracranial pressure headache after lumbar puncture had significant efficacy.The symptoms of headache had been alleviated.It is worth popularization and application in clinical practice generally.