To examine the effect of the Fuma Pingchuan Prescription for Asthma in Experimental Rats and to study its mechanism.Methods：Sixty Clean male rats of SPF.Except the blank control group，all the rats were injected with ovalbumin(OVA) and aluminum hydroxide sensitization，OVA inhalation excited to replicate animal models of asthma.The experimental rats were divided into five groups：the model group(such as volume of distilled water)，positive compare group(377.5 mg/kg)，Fuma Pingchuan Prescription high dose group(49.68 g/kg)，middle dose group(24.84 g/kg) and low dose group(12.42 g/kg).Each group consists of ten rats.The rats started to receive intragastric administration 2 weeks after sensitization，1 dose each day in 8 weeks.After the last administration detected by ELISA in plasma ACTH，serum CORT，IL-4、IFN-γ and IgE levels.Staining the tissue in one side of the lung with HE and detecting β-AR content.In the other side by immunohistochemistry.Results：Fuma Pingchuan Prescription can effectively alleviate asthma，reduce asthma symptoms and improve lung tissue morphology，while significantly elevated serum CORT，plasma ACTH，lung tissue β-AR levels.Conclusion：Fuma Pingchuan Prescription can improve asthma symptoms of model rats，which may be related to the improved functions of HPA axis and immune.