To discuss the pathological transmission feature between lung and large intestine by observing the synchronous dynamic changes of gastrointestinal and lung function，as well as the pulmonary and intestinal histomorphology of rats with pulmonary disease or enteropathy.Methods：To establish “pulmonary disease(chronic bronchitis)” and “enteropathy (ulcerative colitis)”rats models，then synchronously observe the dynamic changes of the pulmonary function，gastrointestinal function，the lung and colon tissue morphology of the models. Results：Besides reduced pulmonary function and inflammatory changes of the lung， the pulmonary disease model rats also suffered from synchronously reduced gastrointestinal function (stomach retention rate，rate of small intestine propulsion) (P<0.01 or P<0.05)，as well as degeneration and necrosis of epithelial cell and inflammatory cells infiltration of colon tissue.Besides reduced gastrointestinal function and inflammatory change of colon tissue，the enteropathy models also suffered synchronously reducing of pulmonary function (P<0.01 or P<0.05) and degeneration，necrosis and inflammatory cells infiltration of bronchial epithelial cell.When the problem in lung of the pulmonary disease model is aggravating，the intestinal problem is synchronously aggravating，and significant lesions appeared at the 50th day after modeling.When the problem in colon of the enteropathy model is aggravating，the pulmonary problem is synchronously aggravating，and significant lesions appeared at the 8th day after modeling. Conclusion：Whether there is transmission between lung and large intestine mainly depends on the pathological damage degree of the original disease.At the same time，the longer the change of the viscera disease lesion，the more obvious of the transmission.