To analyze the differences of main indicators ingredients of Shengmaisan decoction and its concentrated granules，to build characterized map of Shengmaisan concentrated granules by HPLC chromatography，so as to provide the reference for TCM concentrated granules to replace the decoction preparation.Methods：HPLC chromatography was used to compare the characteristic spectrum difference between Shengmaisan decoction and its concentrated granules.Analysis was conducted on the similarity of the two by the similarity software.Results：Shengmaisan concentrated granules got a better separation of the components under the chromatographic conditions，and the characteristic spectrum had nine peaks. Schizandrin and other Index components levels in Shengmaisan decoction were roughly the same as those in the concentrated granules.Conclusion：This method can simultaneously separate index components of Shengmaisan decoction and itsTCM concentrated granules.There is no significant difference between Shengmaisan decoction and its TCM concentrated granules.