Pulseless disease is arteritis of aorta and its branches，which is chronic，multiple and non-specific.Guided by the theory of collateral disease，we propose that the pathogenic process of Pulseless disease accords with the pathogenesis of “collateral system and the vascular system”.We point out that the key to treat this disease is to regulate the blood and collaterals.We should master pathogenesis，and applicate blood activating and stasis eliminating drugs in time and appropriately，and the dose should be twice the conventional dose if necessary.We should not only promote the body resistance but also eliminate pathogenic factors.We emphasize that the therapeutic method of promoting blood circulation and removing blood stasis should be applicated in whole course of the treatment.And provide a new thought to treat Pulseless disease.