To observe the clinical curative effect of vine treatment of the traditional Chinese medicine on early and middle phase of knee osteoarthritis on aged patients. Methods：Seventy four patients meeting the recruiting criteria were randomly divided into treatment group (n=37) and control group (n=37). Patients in the treatment group were given vine treatment of traditional Chinese medicine. The control group gave patients oral administration of loxoprofen sodium capsule and ultrashort. The knee joint function scores were assesed before the treatment, one month and three months after the treatment respectively.Results：One month after the treatment, the scores of both groups were higher compared with the states before treatment, and there was no statistical difference between the both groups in terms of the improvement; three months after the treatment，the scores of both group were higher compared with what it was before treatment, and there was statistical differences between the both groups since the treatment group showed better improvement.Conclusion：The clinical curative effect of vine treatment of traditional Chinese medicine on early and middle phase of knee osteoarthritis on aged patients is significant, and the long term effect is better than NSAIDs.