The clinical study of Jieyu Anshen Dingzhi decoction combined with western medicine was conducted so as to evaluate the efficacy and safety on depression and anxiety state.Methods：To compare the depression and anxiety state in the two groups before and after treatment , and investigate the differences between the two groups.Results：1）After treatment, the score of HAMD and HAMA were significantly reduced (P<0.05). The effective rate in the group applying Jieyu Anshen Dingzhi decoction combined with Paroxetine reached to 97.4%. And the effective rate was 89.7% in the control group. 2）The incident rate of adverse reaction in the group of Jieyu Anshen Dingzhi decoction combined with Paroxetine was 17.9%, while that of the control group was 69.2%. There was significant difference between the two groups (P<0.01).Conclusion：Jieyu Anshen Dingzhi decoction combined with western medicine has irrefutable clinical efficacy on depression, which is safe and effective treatment. And the adverse reaction is way less than Paroxetine.