To observe hepatoprotective role of apple polyphenols (AP, Appjfnol) on immunological liver injury in mice.Methods： An immunological liver injury model in mice was established by intravenous injection of Bacillus Calmette-Guerin (BCG) and lipopolysaccharide (LPS). The liver index and spleen index, the activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), the levels of serum total protein (TP), albumin (Alb) and albumin/globulin (A/G) were detected. Histopathologic change was also investigated by HE staining. Results： AP inhibited the increases of liver index and spleen index, prevented the increase of serum AST activity and the decrease of serum TP and Alb levels. Histopathological abnormalities were also improved after AP administration. Conclusion： AP played a significant hepatoprotective role against BCG and LPS induced immunological liver injury in mice.