After summarizing the related literature analysis and research in recent years，this paper explores the TCM syndrome type characteristics and the change rule of chronic renal aailure from the disease of TCM，western medicine etiology，complications，objective physicochemical index and old doctor of traditional Chinese medicine in treating experience，in order to standardize the syndrome differentiation of TCM of CRF，further guide the rational use of drugs，so as to achieve the goal of alleviating the progression of renal failure.