To observe clinical efficacy of Guipi Decoction in the treatment of anemia in patients undergoing hemodialysis. Methods:74 hemodialysis patients were divided into treatment group and control group according to the random number table, the control group used routine treatments, the treatment group used Guipi Decoction in addition to routine treatments. Hct、Hb、RBC、Ts and SF of two groups were compared. Results:1)the total effective rate of treatment group was 91.9% (34/37), significantly higher than 73.0% of the control group, the difference was statistically significant (P<0.05). 2)After treatment, in the treatment group, the Hct was (32.15±4.22)%, Hb levels (97.36±13.16) g / L, Ts was (30.51±7.41)%, SF content was (155.21±132.56) ug / L, all were better than the control group, the differences were statistically significant (P<0.05). Conclusion:Guipi Decoction was effective for treating anemia in hemodialysis patients, it can widely used in clinical medicine.