Abstract Objective： To observe cardiovascular events，changes of laboratory parameters，and carotid internal media thickness in diabetic patients applied with different treatment regimens.Methods:Sixty-seven patients were divided into 2 groups，both groups were treated with western medicines，the Chinese medicine group was treated with Naoxintong in addition.After 1 years of continuous treatment，therapeutic effect was evaluated based on incidence of cardiovascular events，IMT， blood glucose and lipids，glycated hemoglobin and other biochemical indicators.Results:There were significant blood lipid differences after treatment in both treatment groups (P<0.05)，and the difference was significant between 2 groups (P<0.05).There was statistical significance before and after treatment in Chinese medicine group in IMT，blood glucose，glycosylated hemoglobin protein index (P<0.05)，while the control group before and after treatment had no significant difference (P>0.05)，there was significant difference between 2 groups (P<0.05).The Chinese medicine group had less cardiovascular event incidence compared with the control group.Conclusion:Naoxintong has good effect for treating blood glucose and blood lipids which helps to prevent incidence of cardiovascular events in diabetic patients.