To investigate the clinical efficacy of Beisheng granules in treating stage Ⅲ to Ⅳ diabetic nephropathy. Methods:Sixty four patients with stage Ⅲ to Ⅳ diabetic nephropathy was selected, and randomly divided into control group (n=32) and treatment group (n=32) using the parallel study method. Patients in both groups were treated with conventional therapy, and the treatment group applied extra Beisheng granules for 12 weeks. The improvement of clinical efficacy, clinical symptoms and glomerular filtration rate (GFR), microalbuminuria (uAlb), 24 hour urinary protein quantitative, C reactive protein (CRP), Cystatin C (CYS-C), β 2-microglobulin (β 2-MG) of patients in both groups after treatment were compared. Results: The total efficiency of the treatment group and the control group after 12 weeks of treatment were 78.13% and 59.38% respectively, and there was significant difference between the two groups (P<0.01); the improvement of the clinical symptoms and biochemical indexes were more obvious in the treatment group compared with those of the control group, and there was statistically significant difference between the two groups (P<0.05), there was no significant difference between the two groups in terms of the changes of glycosylated hemoglobin (P>0.05). Conclusion: Beisheng granules can significantly improve the stage Ⅲ to Ⅳ diabetic nephropathy, and at the same time, it can reduce urinary protein, improve the micro inflammatory state in patients, and improve the glomerular filtration rate. It shows good curative effect to treat diabetic nephropathy.