Abstract Objective： To observe the clinical therapeutic effect of articular injection of sodium hyaluronate combined with warm needle in treating knee osteoarthritis (OA).Methods:Sixty three OA patients treated in outpatient clinic of our department from September 2012 to June 2013 were randomly divided into sodium hyaluronate group and combination treatment group.Patients in the sodium hyaluronate group received articular injection of sodium hyaluronate，and patients in combination treatment group were given warm acupuncture and knee articular injection of sodium hyaluronate.The clinical efficacy of two group was observed through the evaluation of visual analogue pain (VAS) score，and Lysholm knee rehabilitation scores (LKSS).Results:After treatment，the differences of VAS score and LKSS score between the two groups were statistically significant.Both groups had lower VAS scores and higher LKSS after treatment，and the differences were both statistically significant (P<0.05).Between the two groups，after treatment，VAS scores of the combined treatment group was lower than that of the sodium hyaluronate group，while LKSS score was higher than that of sodium hyaluronate group.Difference of symptom score between the two groups after treatment was statistically significant.Conclusion:Articular injection of sodium hyaluronate combined with warm needle in the treatment of knee osteoarthritis has definite effect，and it has convenient operation process which is worthy of clinical application.