The change of the tumor microenvironment is one of important factors that cause the aggravation, metastasis, and recurrence of the tumor. By controlling some of the factors such as the oxygen deficiency, the acid environment, interstitial cell voltage and some growth factors can overcome the immune tolerance, promote vascular normalization, and inhibit the proliferation and differentiation of tumor. Therefore, using Chinese herbs mechanisms of anti-tumor to change the tumor microenvironment will open up a brand new field for tumor treatment.