To explore the specific relations between “Hegu” point and orofacial region mainly based on EMG.Methods:The healthy adults and the aged volunteers were acupunctured and the healthy infants were pressed on “Hegu” point to observe the effects of EMG in orofacial muscles.Results:For the healthy volunteers aged 20～30 acupunctured at “Hegu” point，the EMG response is most related with the ipsilateral and contralateral orbicularisoris muscles.For the old healthy volunteers aged 65～75 acupunctured at “Hegu” point，the EMG response is most related with the both side of orbicularisoris muscles and masseter.For the healthy babies between 2 and 6 months old pressed on “Hegu” point，the occurrence rate of the EMG of the facial muscles was 100%.Conclusion:There is specific correlation of the body surface-surface between “Hegu” point and the orofacial region，which is closely related to age factor.